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The inactivation models of Aspergillus parasiticus in mouldy maize by microwave processing were studied in order to describe and predict the inactive effects. Aspergillus parasiticus spores were inactivated under 50～75℃ by microwave processing, then the survival curves were determined. Linear, Weibull and reduced Weibull models were selected to fit the inactivation kinetics of Aspergillus parasiticus spores. Accuracy factor, Bias factor, mean square error and regression coefficients were used to compare the goodnessoffit of the linear, Weibull and reduced Weibull models. The results suggested that Weibull model could provide better fit to the inactivation of Aspergillus parasiticus spores by microwave processing than linear model. The reduced Weibull model produced a fit as good as the original Weibull model and lead to an improvement of the robustness of the model, which would be beneficial to select optimum combinations of temperature and time to obtain the desired target levels of spores inactivation. Incomplete or excessive sterilization could be avoided when Weibull model was used to predict microwave sterilization time instead of linear model.