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The interphase drag for diluted solid—liquid two-phase flow is important for solid volume concentration calculation. The Wen—Yu drag model is widely used in solid—liquid two-phase flow numerical simulation. However, the drag coefficient in Wen—Yu drag model was obtained by adding concentration variable to standard drag coefficient curve, and the influence of fluid turbulence on drag coefficient was ignored. Thus, the influence of fluid turbulence on drag coefficient was considered. The inertia factor and turbulence factor were introduced to describe influence of inertia term and turbulence intensity on drag coefficient respectively for diluted solid—liquid two-phase flow, since the influence was caused by inertia effect and turbulence effect. According to experimental and theoretical investigations, a formula form between turbulence modified function and the two factors was proposed. The constant coefficients in the correlation were determined by the least square method using experimental data, then the relation between turbulence modified function and particle Reynolds number, turbulence intensity was obtained. The turbulence modified function was then used to modify Wen—Yu model. A two-phase flow simulation was conducted in a circular tube with modified Wen—Yu model. By comparison with Wen—Yu model, the results showed that the computed solid concentration distributions of modified Wen—Yu model were agreed well with experimental data at different inlet fluid velocities.